Supplemented fasting in the treatment of obesity and diabetes
1979
Genuth, Saul
The exact relationship of obesity to diabetes is not known, but evidence seems to indicate that it creates insulin resistance and nutrient-stimulated beta cell function, which is compensated for by hyperinsulinism. That this form of diabetes should be reversible by weight loss has been demonstrated; however, the major obstacle is to lose weight and maintain weight loss. Carefully monitored supplemented fasting seems to provide an alternative to drugs or surgery; diets containing high quality protein, 300-800 calories, high fluid intake and 100% RDA for all vitamins except E seem to improve nitrogen balance during weight loss. Clinical observations reveal an average of 30% of body weight is lost, with concomitant improvement in plasma glucose. Occasional occurrence of ketonuria or ketoacidosis was seen, necessitating termination of fasting. Other patients did not alter plasma glucose in spite of satisfactory weight loss. Individual assessment of patients is necessary to determine those who can respond to fasting therapy.
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