New Alkaloids and Polyketides from the Marine Sponge-Derived Fungus <i>Penicillium</i> sp. SCSIO41015
2019
Pang, Xiaoyan | Cai, Guodi | Lin, Xiuping | Salendra, Limbadri | Zhou, Xuefeng | Yang, Bin | Wang, Junjian | Wang, Junfeng | Xu, Shihai | Liu, Yonghong
The sponge-derived fungus Penicillium sp. SCSIO41015 cultured on solid rice medium yielded twenty-one compounds (1–21), including two new alkaloids (1 and 2) and one new pyrone derivative (3). Their structures were elucidated by analysis of 1D/2D NMR data and HR–ESI–MS. Their absolute configurations were established by single-crystal X-ray diffraction analysis and comparison of the experimental with reported specific rotation values. Compound 16 exhibited selective cytotoxic activity against the human gastric cancer cells MGC803, with IC<inf>50</inf> value of 5.19 μM. Compounds 9 and 18 showed weak antibacterial activity against Staphylococcus aureus and Acinetobacter baumannii, respectively, both with MIC values of 57 μg/mL. Furthermore, compound 16 displayed potent antibacterial activity against S. aureus with an MIC value of 3.75 μg/mL.
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