Peniciketals A–C, New Spiroketals from Saline Soil Derived Penicillium raistrichii
2014
Liu, Wei-Zhong | Ma, Li-Ying | Liu, De-Sheng | Huang, Yuling | Wang, Chun-Hua | Shi, Shou-Sen | Pan, Xiao-Hong | Song, Xiao-Dong | Zhu, Rong-Xiu
Peniciketals A–C (1–3), three new spiroketals with a benzo-fused 2,8-dioxabicyclo[3.3.1]nonane moiety, were isolated from the saline soil derived fungus Penicillium raistrichii. Their structures including absolute configurations were established by NMR, X-ray diffraction, and ECD calculations. Their cytotoxicities were tested against A549, HL-60, and K562 cell lines, and 1–3 showed the selective effects on HL-60 cells with IC₅₀ values of 3.2, 6.7, and 4.5 μM, respectively.
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