Reduktion cyclischer Maleinsäurederivate/Reduction of Cyclic Maleic Acid Derivatives
2014
Stachel, Hans-Dietrich | Schachtner, Josef | Seidel, Josef
A series of potentially cytotoxic α,β-unsaturated γ -hydroxy-butyrolactones, -lactams and -thiolactones has been synthesized via regioselective hydride reduction of the appropriate maleic acid anhydrides, imides and thioanhydrides. By this means a straightforward access to naturally occurring antibiotic narthigenine 2, its hitherto unknown thio-analogue 5b and higher substituted derivatives and analogues of 2 is presented.
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