Cytotoxic isoflavones from Erythrina indica

Nkengfack, A.E.; Azebaze, A.G.B.; Waffo, A.K.; Fomum, Z.T.; Meyer, M.; Van Heerden, F.R.

Cytotoxic isoflavones from Erythrina indica

2001

Bioassay-directed fractionation of the CH2Cl2-MeOH (1:1) extract of the stem bark of Erythrina indica, has resulted in the isolation of two new isoflavone derivatives named indicanines D and E together with 11 known compounds including: six isoflavones (genistein, wighteone, alpinumisoflavone, dimethylalpinumisoflavone, 8-prenyl erythrinin C, and erysenegalensein E), one cinnamate (erythrinassinate B), two pentacyclic triterpenes (oleanolic acid and erythrodiol), and two phytosterols (stigmasterol and its 3-O-beta-D-glucopyranoside). The structures of the new compounds were elucidated by means of spectroscopic analysis. The in vitro cytocidal activity against KB cells of some of the isolated compounds is also reported.

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AGROVOC Keywords

antineoplastic agents bark cell lines chemical structure chemistry cytotoxicity fabaceae humans isoflavones isoflavones neoplasms nigeria pharmacology spectral analysis stems

Bibliographic information

Published in

Phytochemistry

Volume 58 Issue 7 Pagination 1113 - 1120 ISSN 0031-9422

Other Subjects

Phytogenic; Spectrum analysis; Isolation & purification; Antitumor; Drug screening assays; Tumor cells; Cultured; Erythrina variegata; Bioassays; Chemical constituents of plants; Derivatives

Language

English

Type

Journal Article; Text

In AGRIS since: 2024-02-28

Format: MODS

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Cytotoxic isoflavones from Erythrina indica

2001

AGROVOC Keywords

Bibliographic information