Cytotoxic Clerodane Diterpenes from Zuelania guidonia
2014
Calderón, Carlos | De Ford, Christian | Castro, Víctor | Merfort, Irmgard | Murillo, Renato
The leaves of Zuelania guidonia yielded eight new clerodane diterpenes, namely, zuelaguidins A–H (1–8), and the known clerodane diterpene esculentin A (9). Some of these structures contained a 3,6-dihydro-1,2-dioxin moiety. The new compounds were isolated and identified using 1D- and 2D-NMR experiments. All compounds were evaluated for cytotoxicity against the CCRF-CEM (human acute lymphocytic leukemia), CEM-ADR5000 (human acute lymphocytic leukemia resistant to doxorubicin), and MIA-PaCa-2 (human pancreatic carcinoma) cell lines as well as for their selectivity against peripheral blood mononuclear cells from healthy human subjects. Zuelaguidins B, C, and E were the most potent compounds against the CCRF-CEM cell line, with IC₅₀ values ranging from 1.6 to 2.5 μM.
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