Sesquiterpenoids from Artemisia argyi and their NO production inhibitory activity in RAW264.7 cells
2021
Xue, Gui-Min | Xue, Jin-Feng | Zhao, Chen-Guang | Zhao, Zhen-Zhu | Sun, Yan-Jun | Du, Kun | Li, Han-Wei | Feng, Wei-Sheng
Investigation into the chemical diversity of Artemisia argyi led to the discovery of two new (1, 4) and four known (2-3, 5-6) sesquiterpenoids. The new structures were determined via extensive spectroscopic data, including IR, UV, MS, and NMR, and the absolute configurations of these compounds were elucidated by calculated ECD method. All isolates were tested for their inhibitory activity against NO production in RAW 264.7 macrophages, and the isolated sesquiterpenoids exhibited NO production inhibitory activity with IC₅₀ values ranging from 1.91 to 36.52 μM.
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