Metabolism of Tri-n-butylin chloride in male rats
1993
Matsuda, R. | Suzuki, T. | Saito, Y.
Tri-n-butyltin chloride was orally administered to male rats, and the metabolites were investigated. After being divided into organs, blood, and urine, the samples were homogenized and extracted. After purification, the extracts were alkylated with methylmagnesium bromide and the resulting tetraalkylated tin compounds were quantified by gas-liquid chromatography with a flame photometric detector. Analytical results showed that n-butyl(3-carboxypropyl)tin compound in the liver and n-butyl(3- hydroxybutyl)tin compound in the kidney were the main products, respectively. The former metabolite showed a light accumulation in the liver and kidney and the latter in the kidney. n-Butyl(4-hydroxybutyl)- and n-butyl(3-oxobutyl)tin compounds were detected only in the urine in small amounts. Trialkyltin metabolites were not found in any organs, blood, and urine. Depending on the results of administration of possible intermediates, it was found that n-butyl(3-carboxypropyl)tin compound was formed not only from di-n-butyl(3-carboxypropyl)tin chloride and di-n-butyl(4-hydroxybutyl)tin chloride but also from di-n-butyl(3-hydroxybutyl)tin chloride. The metabolic fate of tri-n-butyltin chloride was postulated.
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