Copper(I)-catalyzed direct C-H trifluoromethylation of imidazoheterocycles with Togni’s reagent
2019
Wang, Ruonan | Wang, Jingcai | Tang, Qingxuan | Zhao, Xin | Wang, Junfeng | Leng, Yuting | Wu, Yangjie | Chang, Junbiao | Wu, Yusheng | Zhang, Zhaoda | Wang, Shiwei
A mild and efficient trifluoromethylation of imidazopyridines with Togni’s reagent in the presence of inexpensive base has been realized at room temperature. This methodology has several advantages: (1) using efficient copper(I) as catalyst and inexpensive K3PO4 as base, (2) no additional oxidants required for this reaction. (3) good functional group tolerance. An array of trifluoromethylated imidazopyridines with broad functionalities were obtained in acceptable yields.
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