Enzymatic synthesis of a dihydrobenzofuran neolignan by oxidative coupling
1999
Yeo, Hosup | Lee, Jou Heon | Kim, Jinwoong
The oxidative dimerization of ferulic acid has been carried out using horse-radish peroxidase as catalyst to give a dihydrobenzofuran neolignan (1), the structure of which was elucidated as (2SR, 3RS)-2,3-dihydro-2-(4-hydroxy-3-methoxyphenyl)-3-n-butoxycarbonyl-5-(2E-car-boxyethenyl)-7-methoxybenzofuran by spectroscopic analyses. This compound showed more potent cytotoxicity against several tumor cell lines than the starting material.
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