Synthesis and cytotoxicity of novel 1-arylindolizines and 1-arylpyrrolo[2,1-a]isoquinolines
2021
Nevskaya, Alisa A. | Miftyakhova, Almira R. | Anikina, Lada V. | Borisova, Tatiana N. | Varlamov, Aleksey V. | Voskressensky, Leonid G.
An efficient approach to the synthesis of indolizines and pyrrolo[2,1-a]isoquinolines based on a domino reaction is described. The reactivity of the derivatives and the structure-activity analysis are carried out in a number of the obtained compounds. We found a hit showing high cytotoxicity on tumor cells (IC₅₀ = 5.92 ± 0.08 µM) whose cytotoxic effect is comparable to that of the known topoisomerase I inhibitor camptothecin.
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