Cycloaspeptide A and Pseurotin A from the Endophytic Fungus Penicillium janczewskii
2014
Schmeda-Hirschmann, Guillermo | Hormazabal, Emilio | Rodriguez, Jaime A. | Theoduloz, Cristina
Penicillium janczewskiiK. M. Zalessky was isolated as an endophytic fungus from the phloem of the Chilean gymnosperm Prumnopitys andina. When grown in liquid yeast extractmalt extract-glucose broth, the fungus produced two main secondary metabolites. The compounds were for the first time isolated from this species and identified by spectroscopic methods as pseurotin A and cycloaspeptide A. This is the first report on the production of cyclic peptides by endophytic fungi from Chilean gymnosperms. Pseurotin A and cycloaspeptide A presented low cytotoxicity towards human lung fibroblasts with IC₅₀ ≥ 1000 μm. Pseurotin A showed a moderate effect against the phytopathogenic bacteria Erwinia carotovora and Pseudomonas syringae, with IC₅₀ values of 220 and 112 μg ml⁻¹, respectively.
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