Interactions at the Peptide/Silicon Surfaces: Evidence of Peptide Multilayer Assembly
2016
Pápa, Zsuzsanna | Ramakrishnan, Sathish Kumar | Martín, Marta | Cloitre, Thierry | Zimányi, László | Marquez, Jessica | Budai, Judit | Tóth, Zsolt | Gergely, Csilla
Selective deposition of peptides from liquid solutions to n- and p-doped silicon has been demonstrated. The selectivity is governed by peptide/silicon adhesion differences. A noninvasive, fast characterization of the obtained peptide layers is required to promote their application for interfacing silicon-based devices with biological material. In this study we show that spectroscopic ellipsometry—a method increasingly used for the investigation of biointerfaces—can provide essential information about the amount of adsorbed peptide material and the degree of coverage on silicon surfaces. We observed the formation of peptide multilayers for a strongly binding adhesion peptide on p-doped silicon. Application of the patterned layer ellipsometric evaluation method combined with Sellmeier dispersion led to physically consistent results, which describe well the optical properties of peptide layers in the visible spectral range. This evaluation allowed the estimation of surface coverage, which is an important indicator of adsorption quality. The ellipsometric findings were well supported by atomic force microscopy results.
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