Hydrazine as Facile Nitrogen Source for Direct Synthesis of Amines over a Supported Pt Catalyst
2020
Wang, Jing | Ye, Sen | Liu, Xiang | Loh, Teck-Peng
Facile preparation of secondary amines from alcohols or aldehydes is achieved by using the hydrazine (N₂H₄) as an easy-to-handle nitrogen source. The anatase titania-supported Pt (Pt/TiO₂-A) is discovered to be an efficient catalyst to enable the first alcohols/aldehydes to amines conversion with N₂H₄ as the only nitrogen and hydrogen source without any additional base or additives. Mechanistic studies suggest that this alcohol-to-amine transformation proceeds by the sequential alcohol dehydrogenation, aldehyde-N₂H₄ condensation, azine reduction, imine formation, and reduction processes in one pot. As N₂H₄ is a strong nucleophile that readily reacts with aldehyde, the unique catalytic property of Pt/TiO₂-A ensures the high selectivity of amine products by providing multifunctional active sites for dehydrogenation and multiple reductions. This study highlights the considerable potential of hydrazine in direct synthesis of nitrogen-containing fine chemicals with a fine-tuned heterogeneous Pt catalyst, which is safe, green, and easy to handle.
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