Synthesis of Pyrido[1,2-a]indole Malonates and Amines through Aryne Annulation
2012
Rogness, Donald C. | Markina, Nataliya A. | Waldo, Jesse P. | Larock, Richard C.
Pyrido[1,2-a]indoles are known as medicinally and pharmaceutically important compounds, but there is a lack of efficient methods for their synthesis. We report a convenient and efficient route to these privileged structures starting from easily accessible 2-substituted pyridines and aryne precursors. A small library of compounds has been synthesized utilizing the developed method, affording variously substituted pyrido[1,2-a]indoles in moderate to good yields.
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