Design, synthesis and insight into the structure–activity relationship of 1,3-disubstituted indazoles as novel HIF-1 inhibitors
2011
An, Hongchan | Kim, Nam-Jung | Jung, Jong-Wha | Jang, Hannah | Park, Jong-Wan | Suh, Young-Ger
Design, synthesis and insight into the structure–activity relationship (SAR) of 1,3-disubstituted indazoles as novel HIF-1 inhibitors are described. In particular, the substituted furan moiety on indazole skeleton as well as its substitution pattern turns out crucial for the high HIF-1 inhibition.
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