Toxicité aiguë et activité analgésique de l'extrait méthanolique de Rumex nervosus Vahl | Acute toxicity and analgesic activity of the methanolic extract of Rumex nervosus Vahl
2012
Alwashli, A. | Al Sobarry, M. | Cherrah, Y. | Alaoui, K.
Rumex nervosus Vahl has been used traditionally for treatment of inflammatory and painful condition in Yemen. We performed the central and peripheral analgesic activity by using both pharmacological tests, Koster and tail flick.The DL50 value is 1028 mg/kg (per os) with limits of confidence at 95% (723.6<DL50<1416).The methanolic extract of Rumex nervosus Vahl produced an important peripheral analgesic effect, with a power of protection against the abdominal cramp, about 32% at 50 mg/kg and 43% at 100 mg/kg, via oral pathway. Moreover, a low central analgesic activity morphine like appears to 100 mg/kg.
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