Pharmacokinetics of moxidectin in alpacas following administration of an oral or subcutaneous formulation
2016
Cocquyt, Christine M. | Van Amstel, Sarel | Cox, Sherry | Rohrbach, Barton | Martín-Jiménez, Tomás
The purpose of this study was to evaluate the pharmacokinetics of moxidectin in alpacas after single subcutaneous injection of a non-aqueous formulation or oral administration of an aqueous drench at 0.2mg∗kg−1. Plasma moxidectin concentrations were measured with reverse phase HPLC, and data analyzed using non-compartmental methods.Half-life was longer (p=0.02) after subcutaneous administration than oral (292+/−170 vs 33+/−39h). The area under the concentration–time curve was greater (p=0.04) following subcutaneous administration (1484.8+/−1049.5h∗ng∗ml−1) than oral (157.6+/−85.9h∗ng∗ml−1). The peak concentration (Cmax) was higher and the after subcutaneous administration, but the difference was not statistically significant (p=0.18). The relative bioavailability of the oral moxidectin to the subcutaneous moxidectin was 11%.The data suggest a higher relative bioavailability following subcutaneous compared to oral administration. Further studies are needed to determine the therapeutic concentrations of moxidectin in alpacas.
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