Stereoselective esterification of halogen-containing carboxylic acids by lipase in organic solvent: effects of alcohol chain length
1990
Pan, S.H. | Kawamoto, T. | Fukui, T. | Sonomoto, K. | Tanaka, A.
Optical resolution of racemic carboxylic acids containing a halogen atom was attempted with stereoselective esterification by Celite-adsorbed hydrolases in organic solvents. As lipase OF 360 from Candida cylindracea was found to stereoselectively esterify 2-(4-chlorophenoxy)propanoic acid, the (R)-enantiomer (d-isomer) of which is an important herbicide, the effects of alcohol chain length on stereoselectivity as well as reaction rate were investigated. The results revealed that the alcohol chain length markedly affected the stereoselective esterification of 2-(4-chloro-phenoxy) propanoic acid: longer-chain alcohols, such as tetradecanol, served as excellent substrates for optical resolution of the acid, although the reaction rate was moderate.
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