A highly regioselective Friedländer reaction mediated by lanthanum chloride
2012
Chen, Ying | Huang, Jinkun | Hwang, Tsang-Lin | Li, T.J. | Cui, Sheng | Chan, Johann | Bio, Matthew
A highly efficient and regioselective Friedländer reaction of unsymmetrical 1,3-diketones with 2-aminoaryl aldehydes (ketones) is described. The methodology leads to the synthesis of a broad scope of substituted quinolines in high yield and excellent regioselectivity.
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