Dragmacidol A and dragmacidolide A from the Australian marine sponge Dragmacidon australe
2015
Khokhar, Shahan | Feng, Yunjiang | Carroll, Anthony R. | Campitelli, Marc R. | Quinn, Ronald J. | Hooper, John N.A. | Ekins, Merrick G. | Davis, Rohan A.
Two new secondary metabolites, the xylerythrin derivative dragmacidol A (1) and the steroid dragmacidolide A (2), were isolated from a specimen of the marine sponge Dragmacidon australe, collected off the coast of the Whitsunday Islands in Queensland, Australia. Their structures were fully characterized via analysis of 1D/2D NMR and MS data. The proton-poor structure of 1 was also supported through successful 13C DFT-NMR calculations. The isolation of these two metabolites from this sponge genus is quite unusual, given that previous reports of Dragmacidon secondary metabolites have been dominated by indole and β-carboline alkaloids.
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