Six C21 steroidal glycosides from Cynanchum wallichii Wight roots and their multidrug resistance reversal activities
2022
Zhang, Ludi | Yuefang, Lin | min, Huang | Wenbo, Chen | Duan, Lixin | Liu, Zhongqiu | Lu, Linlin | Zhang, Rong-Rong
Six unidentified C₂₁ steroidal glycosides, cynwallosides A−F, as well as twenty-two known compounds, were isolated from the roots of Cynanchum wallichii Wight. The structures of cynwallosides A−F were determined by spectroscopic analysis and acidic hydrolysis. Most of these twenty-eight compounds were found to significantly reverse drug resistance in both the MCF-7/ADR and HepG2/ADM cell lines by suppressing P-gp protein expression. Further investigation revealed that three compounds suppressed P-gp expression by significantly inactivating the JNK and NF-κB pathways.
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