Isolation, identification and characterization of the aminoacylase inhibitors from actinomycetes
1992
Tanaka, H. (Okayama Univ. (Japan). Faculty of Agriculture) | Inagaki, K.
We carried out the screening of aminoacylase inhibitors from actinomycetes, and found two kinds of inhibitors in the culture broth. One of them, purified to homogeneity by various column chromatographies, was identified as recemic lactic acid by comparison with the authentic compound on the basis of studies by nuclear magnetic resonance, mass, and infrared spectrometries. Only its L-isomer, however, showed inhibitory activity, and the enzyme activity was inhibited non-competitively in L-lactic acid against N-acetyl-L-methionine. Several other alpha-hydroxy-carboxylic acids, such as L-alpha-hydroxy-n-caproic acid and L-beta-phenyl-lactic acid, inhibited the aminoacylase reaction with a higher inhibitory activity than L-lactic acid
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