Stimulation of spore formation, mycelial growth and thiostrepton production by several thiol compounds and beta-NAD in Streptomyces azureus ATCC 14921 and its derivatives
1993
Ogata, S. (Kyushu Univ., Fukuoka (Japan). Faculty of Agriculture) | Tawara, Y. | Tokunaga, S. | Mise, O. | Matsubara, H. | Rodprapakorn, M. | Hara, T. | Kinoshita, C. | Choi, W.Y.
Sporulation-stimulating compounds were screened by using mutant PK100a of Streptomyces azureus ATCC 14921 (wild-type strain PK0), in which spore formation was inhibited by a pock-forming plasmid pSA1.1. On agar media, L- and D-cysteines, bacitracin, glutathione, and beta-NAD induced the formation of colored spores or spore mass of the strain PK100a. These compounds also stimulated the spore formation of strain PK0 and its good spore-forming (plasmid-free) stain PK100C, and the growth of aerial and submerged mycelia of these three strains. L- and D-cysteines allowed 1.3 to 1.4-fold increase in the production of antibiotic thiostrepton in strains PK0 and PK100C. The thiostrepton production of strain PK100a, which hardly produced it, was also increased by L- D-cysteines by as much as 20% of that of strain PK0
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