Safety of the immunization with hair keratin as an antigen using oil-adjuvant to cows and their calves, and usage of the carcass as edible meat
1996
Ohta, M. (Tohoku Univ., Sendai (Japan). Faculty of Agriculture) | Uchiwa, H. | Murakami, U.
In an attempt to confirm the safety of immunization with hair keratin using oil-adjuvant to cows and their calves, we investigated the effects of immunization on cows including body temperature, swelling on the injected sites, and tissue damages on the carcass. Birth weight, morbidity and performance of calves were also investigated. Twelve Holstein cows were randomly divided into two groups, one group received subcutaneous injection in the dewlap and the other group received intra-muscular injection in the rump. The cows were immunized 3 times at 4-weeks intervals with 50 mg/2.5ml of hair keratin using 2.5ml of oil-adjuvant. After the first immunization, all cows were examined for rectal temperature for a week and swelling in the injected sites were observed for 6 weeks. Ten weeks after the first immunization, 2 cows in each group were slaughtered and the damages in the tissues of the carcasses caused by the immunization were examined. Birth weight, morbidity, performance of calves were compared between 20 calves born to immunized dams and those of 18 calves born to unimmunized dams. There were no effects of immunization on rectal temperature of cows. The swelling on the sites off injection was observed at least until the sixth week after injection in both groups. Carcass inspection found muscle tissue damages in the sites of injection administered 2 to 10 weeks before slaughter in 2 cows which were immunized intra-muscularly in their rump, and these affected areas were cut out and disposed. In the case of cows which were immunized subcutaneously in the dewlap, one of the 2 cows had a tissue damage in the sites of injection administered 2 weeks before slaughter while the other one had tissue damages in the sites of injection administered from 2 to 10 weeks before slaughter. These damages, however, existed in fat tissue, and therefore the carcasses were not damaged
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