Studies on the mechanisms regulating spermatogenesis in rats
1999
Noguchi, J. (National Inst. of Agrobiological Resources, Tsukuba, Ibaraki (Japan))
Spermatogenesis is a complex process which includes mitosis, meiosis and differentiation of haploid cells. Systemic as well as local regulation of spermatogenesis has been reported but these mechanisms are not fully understood. This study wad designed to clarify the hormonal regulation of spermatogenesis with special reference to ontogeny of inhibin secretion. It was shown that inhibin, which is one of the testicular endocrine factors, began to secrete in Sertoli cells and was involved in the regulation of FSH secretion during the neonatal period. Furthermore, it was postulated that inhibin secretion during this period influenced future production of spermatozoa. For understanding the mechanism of local regulation of spermatogenesis, animals which hate hereditary disorders in spermatogenesis may be useful. The other objective of the present study was to clarify the muse of hereditary disorders in spermatogenesis in the TT rat strain, which was considered as candidate model animal for the analysis of regulatory mechanisms in spermatogenesis. As a result of histopathological, endocrinological and genetic analysis, this strain of rats was shown to be useful model for elucidating the mechanisms of meiosis
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