Hypocholesterolemic effect of indigestible fraction of Chlorella regularis in cholesterol-fed rats
2001
Shibata, S. (Yakult Co. Ltd., Kunitachi, Tokyo (Japan). Inst. for Microbiological Research) | Oda, K. | Onodera Masuoka, N. | Matsubara, S. | Kikuchi Hayakawa, H. | Ishikawa, F. | Iwabuchi, A. | Sansawa, H.
The effects of Chlorella regularis powder (CP) and Chlorella regularis indigestible fraction (CIF) on serum and liver lipid concentrations and on fecal steroid excretion were estimated in rats fed diets containing 5 g/kg cholesterol and 2.5 g/kg sodium cholate. The ingestion of 12.7% CP or 5.3% GIF did not influence food intake or growth. CP and GIF decreased the levels of serum cholesterol, but had no effect on the levels of serum triacylglycerol and phospholipid. Liver cholesterol contents were lower in the CP and GIF groups than in the control group, but CP and GIF did not affect liver triacylglycerol content. CP and GIF increased the total amount of fecal neutral steroids excreted, but did not modify the total bile acid excretion. However, the soluble bile acid concentrations of reconstituted fecal water in the rats fed CP and GIF diets were lower than the control value. Moreover, CP and GIF had a high bile acid binding capacity in vitro. These results indicated that GIF had a hypocholes-terolemic effect and enhanced fecal neutral steroid excretion while decreasing the soluble fecal bile acid concentration
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