Pangenome and genome variation analyses of pigs unveil genomic facets for their adaptation and agronomic characteristics
2024
Li, Dong | Wang, Yulong | Yuan, Tiantian | Cao, Minghao | He, Yulin | Zhang, Lin | Li, Xiang | Jiang, Yifan | Li, Ke | Sun, Jingchun | Lv, Guangquan | Su, Guosheng | Wang, Qishan | Pan, Yuchun | Li, Xinjian | Jiang, Yu | Yang, Gongshe | Groenen, Martien A.M. | Derks, Martijn F.L. | Ding, Rongrong | Ding, Xiangdong | Yu, Taiyong
The development of a comprehensive pig graph pangenome assembly encompassing 27 genomes represents the most extensive collection of pig genomic data to date. Analysis of this pangenome reveals the critical role of structural variations in driving adaptation and defining breed-specific traits. Notably, the study identifies BTF3 as a key candidate gene governing intramuscular fat deposition and meat quality in pigs. These findings underscore the power of pangenome approaches in uncovering novel genomic features underlying economically important agricultural traits. Collectively, these results demonstrate the value of leveraging large-scale, multi-genome analyses for advancing our understanding of livestock genomes and accelerating genetic improvement.
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