Fumagillin-induced chromosome aberrations in mouse bone-marrow cells
2010
Stanimirovic, Z., University of Belgrade, Belgrade (Serbia). Faculty of Veterinary Medicine | Aleksic, N., University of Belgrade, Belgrade (Serbia). Faculty of Veterinary Medicine | Kulic, M., University of Sarajevo, East Sarajevo (Bosnia and Herzegovina). Faculty of Medicine | Maletic, M., University of Belgrade, Belgrade (Serbia). Faculty of Veterinary Medicine
The genotoxicity of fumagillin was evaluated accessing the mitotic index and chromosome aberrations in mouse bone-marrow cells. Mice were given fumagillin orally in doses of 5, 10, and 20 mg/kg bw. All doses significantly reduced the mitotic index. The medium and maximum doses led to significant increases in numerical aberrations. The highest dose induced both structural and numeric aberrations, and insertions on the first pair of autosomes that were amplified in the 1C and 1E regions. These results pointed to the genotoxic potential of fumagillin in the range of medium and maximum doses applied.
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