Response to treatment with triclabendazole in Indonesian cattle naturally infested with Fasciola gigantica
1990
Suhardono, S. Widjajanti | Carmichael, I.H. (Research Inst. for Veterinary Science, Bogor (Indonesia))
Response to suppressive treatment with triclabendazole (TCBZ) was evaluated in a field study using 102 Indonesian cattle naturally infested with Fasciola gigantica. The animals were divided into two groups; one received TCBZ at 12 mg/kg orally every eight weeks for one year while the other remained untreated. Relative to control the Fasciola faecal egg count in treated animals was significantly reduced (P 0.01) to almost zero at all observations. There were no differences between the groups in various blood values and body mass gain. Plasma glutamate dehydrogenase (GLDH) levels in treated animals were reduced to within normal values, whereas those in control remained above normal throughout. Although plasma gamma glutamyl transferase (GGT) levels remained within the normal range in both groups they were consistently higher in control than in treated animals. However both GLDH and GGT levels in control animals were considerably lower than those reported by others in experimental low-level chronic fascioliasis, which suggest that only mild liver damage was caused by small numbers of F. gigantica in these animals. Therefore these natural infestations with F. gigantica may have been of little clinical consequence. It follows that realistic control strategies for fascioliasis in Indonesian cattle require through evaluation of losses due to subclinical disease.
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