Formulation of buccaladhesive antiinflammatory gel prepared from the extract of Clinacanthus nutans Lindau
2001
Soravoot Rujivipat | Nisit Pisutthanan
Extraction of Phaya-Yor leaves (Clinacanthus nutans Lindau.) in glycerin has been proposed for the treatment of ulcerative and anti-inflammatory buccal diseases by topical application. This dosage form gave high spreading property but gave the adhesive property for a short period of time. The purposes of this study were to formulate Phaya-Yor adhesive oral mucosal gel which having long retention time of attachment at the buccae and to evaluate adhesive property of the formulations by in vitro technique. The extraction of Phaya-Yor was performed by maceration with ethanol 50 percent v/v. The alcoholic extract was then formulated into gel containing 5 percent w/w of the extract. Mucoadhesive polymer was employed into gel as the carrier. Finally, the mucoadhesion of prepared gels were tested by using pig's intestine as a model. The results showed that the preparation with Carbopol 940 dispersed in sorbitol provided the best adhesiveness on the pig's intestine. The adhesive property of prepared gels was better than the glycerin solution and Carbopol 940 was appeared to be the best performing mucoadhesive gel in comparison to all other tsted polymers.
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