Anti-proliferative activities of 32 Malaysian plant species in breast cancer cell lines
2008
Siti Syarifah M. M. | Asiah O. | Norhayati I. | Nurhanan M. Y. | Mohd Ilham M. A. | Lili Sahira H.
Anti-proliferative activities of 143 crude extracts obtained from 32 plants collected from the rain forests of Pahang, Malaysia, were evaluated in two breast cancer cell lines, i.e. MCF-7 and T47D, obtained from the American Type Culture Collection, USA. The objective of this study was to bioprospect a list of plants to find out their potential to be developed into anti-cancer drug(s), by means of bioassay guided isolation procedure. Mter performing sulforhodamine-B assay, 13 crude extracts from 11 plant species were found to have active anti-proliferative effects (IC50 s 100 llg mJ-l).
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