Antihyperanaemic and antihyperlipidemic activities of Artocarpus altilis fruit based-diet on alloxan-induced diabetic rats
2017
Aganzi, I. Y. | Ojo, O. A. | Fadaka, O. A. | Jayesimi, K. | Ajiboye, B. O. | Olaoye, O. | Chikezie, G. S.
In West Africa especially in Nigeria uses of Artocarpus altilis fruit (breadfruit) have been used traditionally in the management of diabetes mellitus and its complications. This study was designed to investigate the effect of the Artocarpus altilis fruit (breadfruit) based-diet on fasting blood glucose level, haematological parameters and serum lipid profiles in alloxaninduced diabetic rats. In this study, the in vitro antioxidant parameters were determined on aqueous extract of the Artocarpus altilis fruit, while in the in vivo study thirty-two albino rats (Rattus norvegicus) were used and grouped into four: control, diabetic untreated rats, diabetic rats administered with metformin daily and diabetic rats fed with Artocarpus altilis fruit baseddiet. All rats except those in control group were induced intraperitonially with a single dose of 150 mg/kg of alloxan. The aqueous extract of the Artocarpus altilis fruit contained total phenol, total flavonoid, DPPH, FRAP and Fe²+ chelation. Administration of alloxan significantly increased (p <0.05 ) fasting blood glucose, LDL and VLDL with significant reduction (p< 0.05) in all the haematological parameters and HDL. The feeding of the diabetic rats with Artocarpus altilis fruit based-diet significantly ameliorated all these effects to normal. Therefore, the results suggest that consumption of Artocarpus altilis fruit based-diet by diabetic rats ameliorated antihyperanaemic and antihyperlipidemic complications.
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