In vivo effect of sub-chronic administration of ethanol extract of Rosella (Hibiscus sabdariffa L.) calyx on total blood cholesterol, triglyceride level, and heart histopathologic profile
2018
Ikarini, N. | Mahfudh, N.
Rosella (Hibiscus sabdariffa L.) has been used as traditional medicine. The use of rosella for various therapeutic outcome become increasingly. This research objective was to observe the effect of sub-chronic administration of ethanol extract of rosella calyx on total blood cholesterol,triglyceride level, and the histopathologic profile of the heart. The result showed that treatment of the rosella calyx ethanol extract of 50 mg/kgBW and 100 mg/kgBW for 35 days were significantly decreased the total cholesterol in rat (p<0.05), while treatment with 200 mg/kgBW was not revealed the total cholesterol significantly (p>0.05). The levels of triglyceride blood was also decreased significantly after treatment with the rosella calyx ethanol extract at 50 mg/ kgBW, 100 mg/kgBW, and 200 mg/kgBW dose (p<0.05) respectively. It seem that the effect of lowering total cholesterol level was reversible, but the decreasing effect of triglyceride level was not reversible after two weeks observation. It was found that there were no changes on the heart histopathologic.
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