Passive immunoprophylaxis of edema disease in weaned piglets
Alexa, P.(Vyzkumny Ustav Veterinarniho Lekarstvi, Brno (Czech Republic))E-mail:[email protected] | Hamrik, J. | Stouracova, K. | Konstantinova, L. | Salajka, E.
Hyperimmune sera against Shiga toxin Stx2e with antibody titres 8,000-32,000 were administered subcutaneously to piglets (n=73) 3 days after weaning. In most of the piglets, passively acquired antibodies disappeared during 4 to 8 weeks after application. The recorded serum titres were in all of the piglets 8 or higher fourteen days following administration. In another experiment, an immune porcine serum with antibody titre against Stx2e of 130,000 was applied subcutaneously at different doses. The following day, supernatant of STEC culture with Stx2e titre of 150,000 was applied. Piglets that received 0.2 to 3 mL of serum remained unaffected. Piglets that received 0.05 mL of serum and those of the control group showed severe clinical manifestations of edema disease following Stx2e application. In a group of 3 piglets that received 0.1 mL of serum, mild paralysis was observed in 1 piglet 18 hrs following Stx2e application.
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