Ultrastructural changes of ovaries in rabbits following cadmium administration
Massanyi, P.(Slovenska Polnohospodarska Univ., Nitra (Slovak Republic))E-mail:massanyi@yahoo.com | Uhrin, V.(Slovenska Polnohospodarska Univ., Nitra (Slovak Republic)) | Toman, R.(Slovenska Polnohospodarska Univ., Nitra (Slovak Republic)) | Pivko, J.(Vyskumny Ustav Zivocisnej Vyroby, Nitra (Slovak Republic)) | Lukac, N.(Slovenska Polnohospodarska Univ., Nitra (Slovak Republic)) | Forgacs, Z.(Fodor Jozsef National Center of Public Health, Budapest (Hungary)) | Somosy, Z.(Fodor Jozsef National Center of Public Health, Budapest (Hungary)) | Fabis, M.(Slovenska Polnohospodarska Univ., Nitra (Slovak Republic)) | Danko, J.(Univerzita Veterinarskeho Lekarstva, Kosice (Slovak Republic))
Rabbits received Cd either i.p. (1.5 mg/kg body weight, group A) or in pelleted food at a dose of 1.0 mg/kg b.m. for 5 month (group C). The K group was the control. Qualitative analyses showed numerous changes in the ultrastructure of ovarian cells after Cd administration. Significant decrease of relative volume of mitochondria in group C in comparison with group A was found in granulosa cells. In ovarian thecal cells a significant increase of the relative volume of endoplasmic reticulum in group A in comparison with K group was detected. In ovarian stromal cells a significant increase of the relative volume of smooth membranes was found. In endothelial cells significantly higher amount of mitochondria and cytoplasm in group A were observed. The negative effect of Cd was detected in all studied cell types and we conclude that it is cell-dependent.
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