Haematological and histological bone marrow findings in experimental classical swine fever
1997
Calderon, N.L. | Paasch, L.H. (National Autonomous Univ. of Mexico (Mexico). Faculty of Veterinary Medicine and Animal Science)
Blood coagulation pathways as well as determinations of blood cell counts with special emphasis on platelets in 16 pigs experimentally infected with the classical swine fever virus and in four control pigs were studied. The aforementioned studies were complemented with histological evaluation of bone marrow of the same animals. In this study no significant changes were determined in the variables of intrinsic and extrinsic coagulation pathways, however, a significant reduction of platelet counts was detected starting at the third day post infection. The histological findings consisted in swelling and vacuolation of megakaryocytes observed in the bone marrow at the second day post infection, at four days post infection the megakaryocytes were necrotic. Other outstanding changes were detected in the vascular endothelium after the third day post infection, consisting in severe swelling and necrosis of endothelial cells.
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