Effects of alcohol on the ultrastructures of rat liver
1989
Kim, J.O. | Hah, J.C. (Pusan National Univ., Pusan (Korea Republic). Coll. of Natural Sciences)
To investigate the effect of alcohol on the ultrastructural changes of liver the experiment was undertaken by dividing in 3 groups (control, alcohol and alcohol-carnitine groups). Chronic administration of ethanol to adult rats led to striking fat accumulation and ultrastructural changes in the liver. Mitochondrial abnormalities, dilation of endoplasmic reticulum, focal cytoplasmic degradation, dilation of bile canaliculi and swelling of nucleus were observed. In alcohol-carnitine group, there were less fat accumulation and ultrastructural changes than alcohol group. These alterations suggest that ethanol is very toxic to the liver and carnitine prevents fat accumulation induced by alcohol
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