A possible target for the heat inactivation of SCK tumor cells
1989
Kang, M.S. | Chung, J.Y. (Seoul National Univ., Seoul (Korea Republic). Coll. of Natural Science)
The present investigation aims at inquiring into a possible target for the heat inactivation of SCK tumor cells by comparing the kinetics of cell survival, rate of protein synthesis, and DNA polymerase activity in the presence of heat protector or heat sensitizer. A possible conclusion to be drawn from the present experiment is that there is no direct correlation between cell death and decrease in the rate of protein synthesis, but that the loss of DNA polymerase beta activity correlates quite well with cell inactivation. Thus, protein degradation and/or abnormal protein synthesis causes cell inactivation indirectly, possibly by altering the cellular environment which in turn affects the DNA polymerase beta activity. Accordingly, further studies, dealing with the correlation between changes in the cellular environment and DNA polymerase beta activity, are needed to get insight into a possible target for the heat inactivation of cells
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