Inhibition of Tumor Growth through Macrophage Activation by Polysaccharide Fraction from Peonia japonica (PJ-P)
2003
Park, H.R. | Jung, U. | Jeong, I.Y. | Jo, S.K (Korea Atomic Energy Research Institute, Daejeon, Republic of Korea) | Yee, S.T. (Sunchon National University, Sunchon, Republic of Korea)
The immunomodulatory activity of PJ-P, a polysaccharide fraction extracted from Pa-eonia japonica, were reported in our previous paper. In the present study, we investigated that PJ-P inhibited cancer growth through activation of macrophages. The activities of peritoneal macrophage to induce tumor necrossis factor(TNF)-Ñß, interleukin-1 (IL-1)ÑG, interleukin-6 (IL-6) and interleukin-12 (IL-12) as well as to ingest fluorescence-latex microbeads were enhanced by treatment of PJ-P.
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