Promoting Synthesis of Collagen from Angelica dahurica Root
Jin, M.H.;Lee, S.H.;Kang, S.J.;Cho, W.G.(LG Household and Health Care, Daejeon, Republic of Korea)E-mail:[email protected] | Jung, M.H.;Lim, Y.H.(LG Chemistry, Daejeon, Republic of Korea)
Three coumarin derivatives, which stimulate collagen biosynthesis in human fibroblasts were isolated from Angelica dahurica root which has been used in traditional medicine for cold, headache, discharging blood and women's diseases. Three coumarin derivatives were identified as 5-benzofuranacrylic acid, 6,7-dihydroxy-4-(3-methyl-2-butenyl)-δ-lactone (prangenidin), 5-benzofuranacrylic acid, 6,7-dihydroxy-4-methoxy-δ-lactone (8-hydroxybergapten) and 5-benzofuranacrylic acid, 8-hydroxypsoralen (xanthotoxol) from their spectral data.
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