Effects of β3-Adrenergic Receptor Polymorphism on the Hyperglycemia in Korean Subjects
Oh, H.H;Choi, S.M.;Yang, H.S.;Yoon, Y.S.(Korea Institute of Oriental Medicine, Seoul, Republic of Korea)E-mail:ysyoon@kiom.re.kr | Kim, K.S.(Kirin Oriental Hospital, Seoul, Republic of Korea)
This study was conducted to examine the effects of β3-adrenergic receptor polymorphism on the blood glucose level and obesity in 530 volunteers, who attended a weight loss program in a local obesity clinic. The age differences in total subjects and the distribution of male and female were 26.55±0.31 yr, 9.1% (n=48), 90.9% (n=492). The genotype distribution of β3-AR gene polymorphism were WW type 75%, WR type 22% and RR type 3%. Among many parameters, fasting blood glucose was significantly higher in WR＋RR type (p=0.001) compared with WW type. When the subjects were divided into two groups by 6.105 mmol/L of the fasting blood glucose level, the frequency of hyperglycemia was 23.3% in WW type subjects, while there was a increase to 35.6% in WR＋RR type subjects (p=0.011, χ²-analysis).
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