Cytotoxic Effect of Inonotus obliquus Composition in HCT-15 Human Colon Cancer Cells and AGS Gastric Cancer Cells
Cha, J.Y.;Yoo, J.H.;Cho, Y.S.(Dong-A University, Busan, Republic of Korea)E-mail:choys@daunet.donga.ac.kr | Jeon, B.S.(Gyeongsang National University, Jinju, Republic of Korea) | Moon, J.C.(Hong Jae Green Co., Ltd., Seoul, Republic of Korea)
This study was performed to investigate the cytotoxic effect of the water-extract from Chaga mushroom (Inonotus obliquus) compositions containing powdered green tea in HCT-15 human colon carcinoma, AGS human gastric carcinoma and NIH3T3 mouse normal fibroblast cells using viable cell count and MTT assay. The water-extract from Chaga mushroom compositions induced inhibitory effects on proliferation of HCT-15 and AGS cells in the MTT assay and viable cell count. However, mouse normal NIH3T3 cells were exhibited 80% survival under the same condition. Chaga mushroom compositions showed highly antiproliferative effect in human cancer cell line HCT-15 and AGS, but not in mouse normal cell line NIH3T3.
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