Anti-proliferative Effects of Water Extract of Agaricus blazei Murill in Human Lung Cancer Cell Line A549
Choi, W.Y.;Park, C.;Choi, Y.H.(Dongeui University College of Oriental Medicine, Busan, Republic of Korea)E-mail:[email protected] | Lee, J.Y.(Cheongweon Industrial Farm, Gimhae, Republic of Korea) | Kim, G.Y.;Park, Y.M.(Pusan National University College of Medicine, Busan, Republic of Korea) | Jeong, Y.K.(Dongeui University, Busan, Republic of Korea) | Lee, W.H.(Pusan National University, Busan, Republic of Korea)
Agaricus blazei Murill is a medicinal mushroom native to Brazil. It used to be a source of antitumor and immunoactive compounds and considered a health food in many countries. In the present study, it was examined the effects of water extract of A. blazei (WEAB) on the growth of human lung carcinoma cell line A549 in order to investigate the anti-proliferative mechanism by WEAB. Treatment of A549 cells to WEAB resulted in the growth inhibition, morphological change and induction of apoptotic cell death in a dose-dependent manner as measured by MTT assay and flow cytometric analysis. Flow cytometric analysis revealed that WEAB caused G2/M phase arrest of the cell cycle, which was associated with a down-regulation of cyclin A in both transcriptional and translational levels.
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