Preparation and Immunogenicity of the Combined Vaccine Composed of the Polysaccharide Capsule of Samonella typhi and Japanese Encephalitis Virus
Chee, H.Y.(Konyang University, Nonsan, Republic of Korea) | Kim, E.C.(VaccTech Corp., Daejeon, Republic of Korea)E-mail:[email protected]
The immunogenicity of investigational combined vaccine, composed of the Japanese encephalis virus(JEV) and the polysaccharide capsule(Vi) of Salmonella typhi covalently bound to tetanus toxoid(TT) was evaluated in mice. The mice immunized with combined vaccine elicited higher anti-Vi Immunoglobulin G(IgG) as well as anti-JEV IgG levels than the mice immunized with Vi-TT or JEV alone. The combined vaccine produced four-fold increase in anti-Vi IgG level than Vi-TT alone. In JEV the combined vaccine was significantly more immunogenic than JEV alone and induced six-fold increase in IgG level. Adsorption of combined vaccine onto aluminium hydroxide gel also enhanced IgG level for both Vi and JEV.
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