Isolation of 5α-reductase Inhibitors from Euphorbia jolkinii
2005
Park, S.H. (Yeungnam University, Kyoungsan, Republic of Korea) | Kim, J.A. (Yeungnam University, Kyoungsan, Republic of Korea) | Hua, Xu Guang (Yeungnam University, Kyoungsan, Republic of Korea) | Lee, C.G. (Yeungnam University, Kyoungsan, Republic of Korea) | Choi, J.Y. (Yeungnam University, Kyoungsan, Republic of Korea) | Oh, I.S. (Yeungnam University, Kyoungsan, Republic of Korea) | Son, A.R. (Yeungnam University, Kyoungsan, Republic of Korea) | Chung, S.R. (Yeungnam University, Kyoungsan, Republic of Korea) | Lee, S.H. (Yeungnam University, Kyoungsan, Republic of Korea), E-mail: [email protected]
Twenty eight comopounds were isolated from the whole plant of Euphorbia jolkinii and evaluated for inhibitory effect on 5α-reductase activity. Among the tested compounds, 1-desgalloyl eugeniin, hippomanin A, euphorbin D, exocoecarianin, rugosin E, and pentagalloyl glucose showed potent inhibitory effect on the enzyme activity. The inhibitory potency of rugosin E and euphorbin D, which are dimeric ellagitannins on 5α-reductase activity, was 7- to 8-fold stronger than that of γ-linolenic acid.
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