The mRNA Expression of Radio-Sensitive Genes Exposed to Various Dosage of Ionizing Radiation in U-937 Cell
2004
Kim, J.S. (Kyonggi University, Suwon, Republic of Korea) | Kim, I.G. (Korea Atomic Energy Research Institute, Daejeon, Republic of Korea) | Kang, K.S. (Seoul University, Suwon, Republic of Korea) | Lim, H.Y. (Kyonggi University, Suwon, Republic of Korea) | Oh, Y.K. (Kyonggi University, Suwon, Republic of Korea) | Yoon, B.S. (Kyonggi University, Suwon, Republic of Korea), E-mail: [email protected]
We used cDNA microarray to assess gene expression profiles in hematopoetic cell line, U-937, exposed to low doses of ionizing irradiation. The 1,000 DNA elements on this array were PCR-amplified cDNAs selected from named human cancer related genes. According to the strength of irradiation, the levels of some gene expression were increased or decreased as dose-dependent manner. The gene expressions of Tubulin alpha, protein kinase, interferon-alpha, -beta, -omega receptor and ras homolog gene family H were significantly increased. Especially, Tubulin gene was shown 2.5 fold up-regulated manner under stress of 500 rad irradiation than 200 rad.
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