Changes of Pulmonary Function During 60 days of Welding Fume Exposure Period 1m Sprague-Dawley Rats
2004
Sung, J.H. (Occupational Safety and Health Research Institute, Daejeon, Republic of Korea) | Choi, B.G. (Yonsei University, Wonju, Republic of Korea) | Song, K.S. (Seoul National University, Seoul, Republic of Korea) | Maeng, S.H. (Occupational Safety and Health Research Institute, Daejeon, Republic of Korea) | Kim, S.J. (Occupational Safety and Health Research Institute, Daejeon, Republic of Korea) | Chung, Y.H. (Occupational Safety and Health Research Institute, Daejeon, Republic of Korea) | Han, J.H. (Occupational Safety and Health Research Institute, Daejeon, Republic of Korea) | Hyun, J.S. (Occupational Safety and Health Research Institute, Daejeon, Republic of Korea) | Yu, I.J. (Occupational Safety and Health Research Institute, Daejeon, Republic of Korea), E-mail: [email protected] | Cho, Y.B. (Yonsei University, Wonju, Republic of Korea) | Cho, M.H. (Seoul National University, Seoul, Republic of Korea)
Respiratory effects in full time welders include bronchitis, airway irritation, lung function changes, and lung fibrosis. Welder's pneumoconiosis has been generally determined to be benign and not associated with respiratory symptoms based on the absence of pulmonary function abnormalities in welders with marked radiographic abnormalities. Accordingly, to investigate pulmonary function changes during 60 days induced by welding-fume exposure, male Sprague-Dawley rats were exposed to manual metal arc-stainless steel (MMA-SS) welding fumes with concentrations of 64.8±0.9 mg/㎥ (low dose) and 107.8± 2.6 mg/㎥ (high dose) total suspended particulates for 2 hr/day, 5 days/week in an inhalation chamber for 60 days.
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