Single and Two-Week Repeated Oral Dose Toxicity Study of DHP2, a Hydrophobic Drug Delivery Vehicle in Mice
2004
Han, J.H. (Pharmaceutical Examination Division, KIPO, Daejon, Republic of Korea), E-mail: junghee@kipo.go.kr | Chung, H.S. (Biomedical Research Center, KIST, Seoul, Republic of Korea) | Lee, J.H. (Korea Institute of Toxicology, Daejon, Republic of Korea) | Kim, J.C. (Chonnam National University, Gwangju, Republic of Korea) | Suh, J.E. (Korea Institute of Toxicology, Daejon, Republic of Korea) | Lee, G.S. (Korea Institute of Toxicology, Daejon, Republic of Korea) | Kang, B.H. (Korea Institute of Toxicology, Daejon, Republic of Korea)
The present study was conducted to investigate the single and 2-week repeated dose toxicity of DHP2, a hydrophobic drug delivery vehicle, in ICR mice. The test article was administered orally to mice at the dose levels of 2.5, 12.5 and 37.5 g/kg for single dose toxicity study and at the dose levels of 0, 2.5, 5, and 10 g/kg for repeated dose toxicity study. In both studies, there were no treatment-related effects on mortality, clinical signs, food and water consumption, ophthalmoscopy, urinalysis, hematology, serum biochemistry, necropsy findings and organ weights of all animals treated DHP2.
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