Single and Four-Week Oral Toxicity Studies of Difructose Dianhydrides (DFA Ⅳ) in Sprague-Dawley Rats
2004
Lee, C.W. (Korea Research Institute of Bioscience and Biotechnology, Daejeon, Republic of Korea) | Kim, S.H. (Realbiotech Co., Ltd., Yeongi, Republic of Korea) | Son, H.Y. (Chungnam National University, Daejeon, Republic of Korea) | Lee, M.L. (Korea Research Institute of Bioscience and Biotechnology, Daejeon, Republic of Korea) | Kim, H.M. (Korea Research Institute of Bioscience and Biotechnology, Daejeon, Republic of Korea) | Yoon, W.K. (Korea Research Institute of Bioscience and Biotechnology, Daejeon, Republic of Korea) | Kim, H.C. (Korea Research Institute of Bioscience and Biotechnology, Daejeon, Republic of Korea), E-mail: hckim@kribb.re.kr
This study was to investigate single and repeated-dose toxicities of DFA Ⅳ, a new candidate of nutraceutical which has preventive effect on anemia and osteoporosis. In single-dose oral toxicity study, the test article were administered once by gavage to rats at dose level of 0, 2,000 and 5,000 mg/kg. No dead animal, abnormal sign and abnormal necropsy finding was found in control and treated groups. Thus the approximate lethal dose of DFA IV was considered to be higher than 5,000 mg/kg in rats. In four week repeated dose oral toxicity study, the test article was administered once daily by gavage to rats at dose levels of 0, 500, 1,000 and 2,000 mg/kg.
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